Mokoto Station opened on November 15, 1924, as part of the state-built Senmō Line. It connected the rural area around Abashiri to the growing railway network to Kushiro and facilitated the transport of regional produce. A narrow-gauge railway to Yamazono, opened in 1935, further emphasized its earlier freight function. JR Hokkaido has operated the station since 1987; freight service ceased in 1982.
Sources: Perplexity research, including Senmō Main Line and Mokoto Station.